ywei@shu.edu.cn
魏彦，研究员，博士生导师，生物材料与再生医学研究中心主任，九三学社社员。2015.06：毕业于复旦大学，获药剂学博士学位；2015.07-2017.08：中国科学院上海药物研究所，博士后；2017.10-2020.08：中国科学院上海药物研究所，副研究员；2020.09-2024.02：上海大学转化医学研究院，副研究员/博士生导师；2024.03-至今：上海大学转化医学研究院，研究员/博士生导师。迄今作为第一或通讯作者（含共同）在 Adv. Funct. Mater.、ACS Nano、Adv. Sci.、Biomaterials、J. controlled release、Bioact. Mater.、Acta Pharm. Sin. B、Chem. Eng. J.、Theranostics、Composites, Part B、Drug Discovery Today 等期刊发表SCI论文22篇，累计影响因子255.4；其中，IF > 10的中科院1区论文15篇，ESI高被引5篇，封底2篇。已授权4项中国发明专利。作为项目负责人获中国博士后面上基金（1等）、国家自然科学基金青年项目、面上项目、上海市自然科学基金面上项目、复旦大学克服递药屏障高端制剂国重室开放课题等多项资助。作为主要研制人完成白蛋白结合型紫杉醇纳米药物开发，获2.4类及4类新药临床批件，并通过CFDA临床一致性评价。
主要研究领域：
1. 基于脂质、蛋白的纳米递药系统合理化设计及克服生理病理屏障研究
2. 具有临床应用前景的高端纳米制剂转化研究
3. 肿瘤类器官构建策略与应用
代表性学术成果：
1. Duan, N.#; Li, J.#; Song, S.; Wang, F.; Yang, Y.; Nie, D.; Wang, C.; Sheng, Y.; Tao, Y.; Gao, J.; Xu, C.*; Wei, Y.*; Gan, Y. Enzyme‐Activated Prodrug‐Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells. Adv. Funct. Mater. 2021, 2100605. DOI: 10.1002/adfm.202100605. (IF = 18.808)
2. Wei, Y.#; Song, S.#; Duan, N.; Wang, F.; Wang, Y.; Yang, Y.; Peng, C.; Li, J.; Nie, D.; Zhang, X.; Guo, S.; Zhu, C.; Yu, M.; Gan, Y*. MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy. Adv. Sci. 2020, 1902746. DOI: 10.1002/advs.201902746. (IF = 16.806)
3. Wu, J.#; Cheng, Y.#; Qian, K.; Yang, P.; Zhou, L.; Xu, M.; Sheng, D.; Wang, T.; Li, Y.; Yang, X.; Wei, Y.*; Zhang, Q*. siRNA-Encapsulated Biomimetic Liposomes Effectively Inhibit Tumor Cells’ Hexosamine Biosynthesis Pathway for Attenuating Hyaluronan Barriers to Pancreatic Cancer Chemotherapy. ACS Nano. 2025, 19(8), 7928-7947. DOI: 10.1021/acsnano.4c14969. （IF = 15.8）
4. Cheng, Y.; Xu, M.; Wu, J.; Qian, K.; Yang, P.; Zhou, L.; Meng, R.; Li, Y.; Wang, T.; Sheng, D.; Wei, Y.*; Zhang, Q*. Carcinoma-Astrocyte Gap Junction Interruption by a Dual-Targeted Biomimetic Liposomal System to Attenuate Chemoresistance and Treat Brain Metastasis. ACS Nano. 2024. DOI: 10.1021/acsnano.4c09996. (IF = 15.8)
5. Cao, J.#; Wu, J.#; Yang, P.; Qian, K.; Cheng, Y.; Xu, M.; Sheng, D.; Meng, R.; Wang, T.; Li, Y.; Wei, Y.*; Zhang, Q*. Dual Enzyme Cascade-Activated Popcorn-Like Nanoparticles Efficiently Remodeled Stellate Cells to Alleviate Pancreatic Desmoplasia. ACS Nano. 2023, 17(20), 19793-19809. DOI: 10.1021/acsnano.3c03838. (IF = 17.1)
6. Cao, J.; Yang, P.; Wang, P.; Xu, S.; Cheng, Y.; Qian, K.; Xu, M.; Sheng, D.; Li, Y.; Wei, Y.*; Zhang, Q*. 'Adhesion and Release' Nanoparticle-Mediated Efficient Inhibition of Platelet Activation Disrupts Endothelial Barriers for Enhanced Drug Delivery in Tumors. Biomaterials. 2020, 269, 120620. DOI: 10.1016/j.biomaterials.2020.120620. (IF = 12.479)
7. Yan, J.#; Wang, M.#; Lv, S.#; Chen, D.; Wu, Z.; Zhou, D.; Zhang, S.; Lv, J.; Xu, K.*; Xu, C.*; Wei, Y.*. SiATG5-Loaded Cancer Cell Membrane-Fused Liposomes Induced Increased Uptake of Albumin-Bound Chemotherapeutics by Pancreatic Cancer Cells. J. Controlled Release. 2024, 367, 620-636. DOI: 10.1016/j.jconrel.2024.01.055. (IF = 10.8；ESI高被引)
8. Wu, Z.#; Wu, Y.#; Wang, M.#; Chen, D.; Lv, J.; Yan, J.; Zhou, D.; Pang, Y.; Liang, H.; Zhang, D.; Li, H.*; Wei, Y.*; Xu, C*. FAP-Activated Liposomes Achieved Specific Macropinocytosis Uptake by Pancreatic Stellate Cells for Efficient Desmoplasia Reversal. Chem. Eng. J. 2024, 495, 153369. DOI: 10.1016/j.cej.2024.153369. (IF = 13.3)
9. Zhou, D.#; Wei, Y.#,*; Sheng, S.#; Wang, M.#; Lv, J.; Zhao, B.; Chen, X.; Xu, K.; Bai, L.; Wu, Y.; Song, P.; Cao, L.; Zhou, F.*; Zhang, H.*; Shi, Z.*; Su, J*. MMP13-Targeted SiRNA-Loaded Micelles for Diagnosis and Treatment of Posttraumatic Osteoarthritis. Bioact. Mater. 2024, 37, 378-392. DOI: 10.1016/j.bioactmat.2024.04.010. (IF = 18.9)
10. Guo, Q.; Li, Y.; Xu, S.; Wang, P.; Qian, K.; Yang, P.; Sheng, D.; Wang, L.; Cheng, Y.; Meng, R.; Cao, J.; Luo, H.; Wei, Y.*; Zhang, Q*. Brain-Neuron Targeted Nanoparticles for Peptide Synergy Therapy at Dual-Target of Alzheimer's Disease. J. Controlled Release. 2023, 355, 604-621. DOI: 10.1016/j.jconrel.2023.01.074. (IF = 11.467)
11. Tao, Y.#; Chen, Y.#; Wang, S.#; Chen, W.; Zhou, D.; Chen, D.; Zhang, C.; Wu, Z.; Yan, J.; Zhang, H.*; Wei, Y.*; Su, J*. Optimizing the Modification Density of Acid Oligopeptides to Enhance the Bone-Targeting Activity of Liposomes. Composites, Part B. 2022, 247(110288). DOI: 10.1016/j.compositesb.2022.110288. (IF = 11.322)
12. Yan, J.#; Zhang, H.#; Li, G.#; Su, J.*; Wei, Y.*; Xu, C*. Lipid Nanovehicles Overcome Barriers to Systemic Rna Delivery: Lipid Components, Fabrication Methods, and Rational Design. Acta Pharm. Sin. B. 2024, 14(2), 579-601. DOI: 10.1016/j.apsb.2023.10.012. (IF = 14.5；ESI高被引)
13. Lv, J.#; Du, X.#; Wang, M.#; Su, J.*; Wei, Y.*; Xu, C*. Construction of Tumor Organoids and their Application to Cancer Research and Therapy. Theranostics. 2024, 14(3), 1101-1125. DOI: 10.7150/thno.91362. (IF = 12.4；ESI高被引；封底)
14. Wu, Z.#; Zhang, H.#; Yan, J.#; Wei, Y.*; Su, J*. Engineered Biomembrane-Derived Nanoparticles for Nanoscale Theranostics. Theranostics. 2023, 13(1), 20-39. DOI: 10.7150/thno.76894. (IF = 11.600；ESI高被引；封底)
15. Zhou, D#; Zhou, F#; Sheng, S; Wei, Y*; Chen, X*; Su, J*. Intra-Articular Nanodrug Delivery Strategies for Treating Osteoarthritis. Drug Discov. Today. 2022, 103482. (IF = 8.369；ESI高被引)
16. Wei, Y.*; Lv, J.; Zhu, S.; Wang, S.*; Su, J.*; Xu, C*. Enzyme-Responsive Liposomes for Controlled Drug Release. Drug Discov. Today. 2024, 104014. DOI: 10.1016/j.drudis.2024.104014. (IF = 6.5)
17. Li, J; Duan, N; Song, S; Nie, D; Yu, M; Wang, J; Xi, Z; Li, J; Sheng, Y; Xu, C; Wei, Y*; Gan, Y*. Transfersomes Improved Delivery of Ascorbic Palmitate Into the Viable Epidermis for Enhanced Treatment of Melasma. Int. J. Pharm. 2021, 121059. (IF = 5.875)
科研项目
1. 2025.01-2028.12 国家自然科学基金，面上项目，可“搭乘”体内单核细胞实现肿瘤深部STING激动剂递送及乏氧缓解的脂质体抗胰腺癌研究（82473316）
2. 2023.04-2026.03 上海市自然科学基金，面上项目，双酶响应型纳米粒构建及其高效调控PSCs增敏胰腺癌化疗的研究（23ZR1463300）
3. 2019.01-2022.12 国家自然科学基金，面上项目，一种可促成肿瘤微环境“正常”化而利于胰腺癌纳米药物递送的智能白蛋白纳米载体的研究（81872428）
4. 2018.01-2020.12 国家自然科学基金，青年项目，可穿透胰腺癌双重屏障的肿瘤微环境响应型多级HSA/lipid纳米递药系统研究（81703010）
5. 2016.09-2017.12 中国博士后科学基金第60 批面上资助，1等资助，微环境响应的双功能白蛋白纳米递药系统抗胰腺癌研究（2016M600342）
社会学术兼职
中国抗癌协会第三届纳米肿瘤学专业委员会青年委员；国家自然科学基金通讯评审专家（2019-至今）；Biomaterials Translational青年编委；Exploration青年编委
九三学社上海市第十八届委员会青年委员
参编专著
1. Biomaterials Effect on the Bone Microenvironment；Wiley-VCH；主编章节：Mechanisms for biomaterials reconstruct microenvironment in bone regeneration
2. 医道中国概论；上海大学出版社；主编章节：医学与社会
3. 类器官理论与技术；上海大学出版社；主编章节：肿瘤类器官
