研究方向：
1.单细胞多组学测序技术的开发及应用
2.肿瘤发生机制，复杂疾病机制研究
研究中心主任：
施威扬 博士
研究中心成员：
沈洁 副研究员 姜泉龙 副研究员 侯丽 助理研究员
研究中心代表作：
1.miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data David Hendrix*, Michael Levine, Weiyang Shi*Genome Biology, 2010, 11(4): 1-12
2. FGF3 in the floor plate directs notochord convergent extension in the Ciona tadpole Weiyang Shi*, Sara M. Peyrot, Edwin Munro, Michael Levine*DEVELOPMENT, 2009, 136(1): 23-28
3. Ephrin signaling establishes asymmetric cell fates in an endomesoderm lineage of the Ciona embryo.Shi, Weiyang*; Levine, Mike* DEVELOPMENT, 2008, 135(5): 931-940
4. A single-cell transcriptome atlas profiles early organogenesis in human embryos.Yichi Xu, Tengjiao Zhang, Qin Zhou, Mengzhu Hu, Yao Qi, Yifang Xue, Lihui Wang, Yuxiao Nie, Zhirong Bao*, Weiyang Shi*Nature Cell Biology, 2023/3/16 online https://www.nature.com/articles/s41556-023-01108-w
5. A single-cell analysis of the molecular lineage of chordate embryogenesis.Tengjiao Zhang, Yichi Xu, Kaoru Imai, Teng Fei, Guilin Wang, Bo Dong, Tianwei Yu, Yutaka Satou, Weiyang Shi*, Zhirong Bao*Science Advances, 2020, 6( eabc4773)
6. Mouse Single Islet β Cell Transcriptomic Reveals Sexually Dimorphic Transcriptome and Type 2 Diabetes Genes. Gang Liu, Yana Li, Tengjiao Zhang, Mushan Li, Sheng Li, Qing He, Shuxin Liu, Minglu Xu, Tinghui Xiao, Zhen Shao*, Weiyang Shi*, Weida Li* Genomics, Proteomics & Bioinformatics, 2021 Jun;19(3):408-422
7.Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling. Zhubing Shi, Zhen Zhang, Zhenzhen Zhang, Yanyan Wang, Chuanchuan Li, Xin Wang, Feng He, Lina Sun, Shi Jiao, Weiyang Shi*, Zhaocai Zhou*Journal of Biological Chemistry, 2015, 290(44): 26811-26820
8. Single-cell profiling of peripheral neuroblastic tumors identifies an aggressive transitional state that bridges an adrenergic-mesenchymal trajectory. Xiaojun Yuan, Janith A. Seneviratne, Shibei Du, Ying Xu, Yijun Chen, Qianya Jin, Xuanxuan Jin, Anushree Balachandran, Shihao Huang, Yanli Xu, Yue Zhai, Liumei Lu, Mengjie Tang, Yushuang Dong, Belamy B. Cheung, Glenn M. Marshall, Weiyang Shi*, Daniel R. Carter*, Chao Zhang* Cell Reports, 2022 Oct 4;41(1):111455
9. Mitigating the adverse impact of batch effects in sample pattern detection. Teng Fei, Tengjiao Zhang, Weiyang Shi*, Tianwei Yu*Bioinformatics, 2018, 34(15): 2634-2641
10. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Fugui Zhu, Qianshu Zhu, Dan Ye, Qingquan Zhang, Yiwei Yang, Xudong Guo, Zhenping Liu, Zeyidan Jiapaer, Xiaoping Wan, Guiying Wang, Wen Chen, Songcheng Zhu, Cizhong Jiang, Weiyang Shi*, Jiuhong Kang* Nucleic Acids Research, 2018, 46(12): 6026-6040
