研究方向：
1）细胞外囊泡与骨衰老
2）细胞外囊泡与组织修复
3）细胞外囊泡与早期诊断
研究中心主任：
刘晗 副研究员
研究中心代表性工作：
1.Han Liu#, Ting Cheng#, Guangfeng Li#, Zhidao Xia, Chenglong Wang*, Ke Xu*, Jiacan Su*. Organoid‐tissue extracellular vesicles. Interdisciplinary Medicine. 2025;e20250006. (第一作者，IF 13.6)
2.Mingkai Wang#, Ruiyang Li#, Shihao Sheng#, Zhenglin Dong#, Long Bai, Xiuhui Wang, Jianhua Wang, Yuxiao Lai, Xiao Chen, Xiao Chen, Jie Gao*, Chongru He*, Han Liu*, Jiacan Su*. Combination therapy using intestinal organoids and their extracellular vesicles for inflammatory bowel disease complicated with osteoporosis. Journal of Orthopaedic Translation 53 (2025) 26-36. （通讯作者，医学1区，IF 7.8）
3.Guangyin Zhou,# Qirong Zhou,# Ruiyang Li,# Shihao Sheng,# Qianmin Gao, Dongyang Zhou, Long Bai, Zhen Geng, Yan Hu, Hao Zhang, Xiao Chen, Jian Wang, Yingying Jing,* Ke Xu,* Han Liu,* Jiacan Su*. Synthetically engineered bacterial extracellular vesicles and IL-4-encapsulated hydrogels sequentially promote osteoporotic fracture repair. ACS Nano. 2025. https://doi.org/10.1021/acsnano.5c03106.（通讯作者，材料科学1区 Top，IF 16.0，封面文章）
4.Xiangxiang Kong,# Han Liu,#* Sumeng Chen, Zhinan Liu, Qin Chen, Xiang Li, Honggang Hu*, Jiacan Su*, Yejiao Shi*. Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis. Journal of Controlled Release. 2025. 382, 113751.（通讯作者，医学1区，IF 11.5）
5.Mingkai Wang #, Ruiyang Li#, Shihao Sheng#, Huijian Yang#, Xuan Tang, Jian Wang, Fuxiao Wang, Qin Zhang, Long Bai, Xiao Chen, Jie Gao*, Xiaoxiang Ren*, Han Liu*, Jiacan Su*. MOF nanozyme mediated bacterial metabolic regulation to intervene MRSA antibiotic tolerance for enhanced antimicrobial efficacy. Nano Today 63 (2025) 102753.（通讯作者，材料科学2区 Top，IF 10.9）
6.Sicheng Wang#, Yan Hu#, Peiran Song#, Qiushui Lin#, Xuan Tang, Qianmin Gao, Jian Wang, Dongyang Zhou, Jilong Li, Dan Huang, Long Bai, Xiao Chen, Jie Gao *, Han Liu*, Zhongmin Shi*, Jiacan Su*. Harnessing extracellular vesicles from Lactobacillus reuteri and Lactobacillus paracasei for synergistic osteoporosis therapy. Composites Part B-Engineering. 297 (2025) 112255.（通讯作者，材料科学1区 Top，IF 14.2）
7.Ruina Han#, Dongyang Zhou#, Ning Ji#, Zhifeng Yin#, Jian Wang, Qin Zhang, Hao Zhang, Jinlong Liu, Xinru Liu*, Han Liu*, Qinglin Han*, Jiacan Su*. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. Journal of Nanobiotechnology. 23, 41 (2025). （通讯作者，生物学1区 Top，IF 12.6）
8.Han Liu#, Peiran Song#, Hao Zhang#, Fengjin Zhoue#, Ning Ji, Mingkai Wang, Guangyin Zhou, Ruina Han, Xinru Liu, Weizong Weng, Haoqi Tan, Sicheng Wang*, Lei Zheng*, Yingying Jing*, Jiacan Su*. Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 ameliorate osteoporosis. Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 to ameliorate osteoporosis. Journal of Extracellular Vesicles. 2024;13:e12429（第一作者，医学1区 Top，IF 14.5）
9.Han Liu#, Ruiyang Li#, Huijian Yang#, Bo Situ*, Guangchao Wang*, Ke Xu*, Jiacan Su*. Extracellular vesicles in gut-bone axis: Novel insights and therapeutic opportunities for osteoporosis. Small Science. 2024. 2400474. DOI: 10.1002/smsc.202400474.（第一作者， IF 8.3，封面文章）
10.Guangyin Zhou#, Ruiyang Li#, Shihao Sheng#, Jingtao Huang#, Fengjin Zhou*, Yan Wei*, Han Liu*, Jiacan Su*. Organoids and organoid extracellular vesicles-based disease treatment strategies. Journal of Nanobiotechnology. 2024. doi:10.1186/s12951-024-02917-3.（通讯作者，生物学1区 Top，IF 12.6）
11.Han Liu#, Jiacan Su*. Artificial intelligence-enabled studies on organoid and organoid extracellular vesicles. Biomaterials Translational. 2024, 5(2), 93-94. （第一作者）
12.Yuan-Wei Zhang#, Pei-Ran Song#, Si-Cheng Wang#, Han Liu*, Zhong-Min Shi*, Jia-Can Su*. Diets intervene osteoporosis via gut-bone axis. Gut Microbes. 2024. 16:1, 229543（通讯作者，医学1区 Top，IF 11.0）
13.Mingkai Wang#, Yan Wu#, Guangfeng Li#, Qiushui Lin#, Wencai Zhang*, Han Liu*, Jiacan Su*. Articular cartilage repair biomaterials: strategies and applications. Materials Today Bio 24 (2024) 100948.（通讯作者，医学1区，IF 10.2，ESI高被引）
14.Ruina Han#, Yan Wu#, Yafei Han#, Xiangfei Liu*, Han Liu*, Jiacan Su*. Engineered plant extracellular vesicles for autoimmune diseases therapy. Nano Research. 2024. 17, 2857-2873.（通讯作者，材料科学1区 Top，IF 9.0，年度最佳封面文章）
15.Yan Wu#, Peiran Song#, Miaomiao Wang#, Han Liu*, Yingying Jing*, Jiacan Su*. Extracellular derivatives for bone metabolism. Journal of Advanced Research. 2024.66. 329-347. doi.org/10.1016/j.jare.2024.01.011.（通讯作者，综合1区 Top，IF 13.0）
16.Yan Hu#, Xiaoqun Li#, Xiao Chen#, Sicheng Wang#, Liehu Cao, Hao Zhang, Yunfei Zhang, Zhiwei Wang, Baoqing Yu, Peijian Tong, Qiang Zhou, Feng Niu, Weiguo Yang, Wencai Zhang, Shijie Chen, Qiang Yang, Tao Shen, Peng Zhang, Yong Zhang, Jun Miao, Haodong Lin, Jinwu Wang, Lei Wang, Xin Ma, Hongjian Liu, Ilia Stambler, Long Bai, Han Liu, Yingying Jing, Guohui Liu, Xinglong Wang, Dongliang Wang*, Zhongmin Shi*, Robert Chunhua Zhao*, Jiacan Su*.Expert consensus on Prospective Precision Diagnosis and Treatment Strategies for Osteoporotic Fractures. Aging and Disease. 2024.（骨质疏松性骨折精准诊疗专家共识，医学3区，JCR Q1，IF 6.9）
17.Han Liu#, Yan Wu#, Fuxiao Wang#, Sicheng Wang#, Ning Ji, Mingkai Wang, Guangyin Zhou, Ruina Han, Xinru Liu, Weizong Weng, Wencai Zhang, Haoqi Tan, Yingying Jing, Wencai Zhang*, Hao Zhang*, Zhongmin Shi*, Jiacan Su*. Bone-targeted engineered bacterial extracellular vesicles delivering miRNA to treat osteoporosis. Composites Part B-Engineering. 2023. 267, 11047.（第一作者，材料科学1区 Top，IF 14.2）
18.Han Liu#, Hao Zhang#, Sicheng Wang#, Jin Cui, Weizong Weng, Xinru Liu, Hua Tang, Yan Hu, Xiaoqun Li, Kun Zhang, Fengjin Zhou*, Yingying Jing*, Jiacan Su*. Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis. Composites Part B-Engineering. 2023. 225, 110610（第一作者，材料科学1区Top，IF 14.2）
19.Han Liu#, Jinru Sun#, Mingkai Wang#, Sicheng Wang*, Jiacan Su*, Can Xu*. Intestinal organoids and organoids extracellular vesicles for inflammatory bowel disease treatment. Chemical Engineering Journal. 2023. 465, 142842.（第一作者，工程技术1区 Top，IF 13.2）
20.Han Liu, Jiacan Su*. Organoid and organoid extracellular vesicles for osteoporotic fractures therapy: current status and future perspectives. Interdisciplinary Medicine. 2023. e20230011.（第一作者，IF 13.6）
21.Han Liu#, Jiacan Su*. Organoid extracellular vesicle-based therapeutic strategies for bone therapy. Biomaterials Translational. 2023, 4(4), 199-212. （第一作者，封面文章）
22.Ning Ji#, Fuxiao Wang#, Miaomiao Wang#, Wencai Zhang*, Han Liu*, Jiacan Su*. Engineered bacterial extracellular vesicles for central nervous system diseases. Journal of Controlled Release. 2023.364 (2023) 46-60.（通讯作者，医学1区，IF 11.5）
23.Shuming Sun#, Han Liu#, Yan Hu, Yanpeng Wang, Mingri Zhao, Yijun Yuan, Yafei Han, Yingying Jing, Jin Cui*, Xiaoxiang Ren*, Xiao Chen*, Jiacan Su*. Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle. Bioactive Materials. 2023, 3, 166-178.（共同一作，医学1区 Top，IF：20.3，封面文章，ESI高被引）
24.Minghui Wen#, Jingyu Wang#, Zihao Ou#, Guangjun Nie, Ye Chen, Min Li, Zhiwei Wu, Sidong Xiong, Hongwei Zhou, Zifeng Yang, Gang Long, Jiacan Su, Han Liu, Yingying Jing, Zhenke Wen, Yuxuan Fu, Tieli Zhou, Hui Xie, Wenda Guan, Zhang Wang, Juan Wang, Xunxun Chen, Linglei Jiang, Xiaolin Qin, Yicong Xue, Mei Huang, Xinyue Huang, Ruoru Pan, Haojun Zhen, Yuqi Du, Qianbei Li, Xixin Huang, Yuanyuan Wu, Pingping Wang, Kening Zhao, Bo Situ*, Xiumei Hu*, Lei Zheng*. Bacterial extracellular vesicles: A position paper by the microbial vesicles task force of the Chinese society for extracellular vesicles. Interdisciplinary Medicine. 2023;1: e20230017.（细菌外囊泡研究专家共识，IF 13.6）
25.Han Liu#, Qin Zhang#, Sicheng Wang#, Weizong Weng*, Yingying Jing*, Jiacan Su*. Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives. Bioactive Materials. 2022. 14, 169-181（第一作者，医学1区Top，IF：20.3，ESI高被引）
26.Han Liu#, Mengmeng Li#, Tao Zhang# , Xinru Liu*，Hao Zhang*, Zhen Geng*，Jiacan Su*. Engineered bacterial extracellular vesicles for osteoporosis therapy. Chemical Engineering Journal. 2022. 450 (4), 13809（第一作者，工程技术1区 Top，IF 13.2）
27.Han Liu#, Hao Zhang#, YaFei Han#, Yan Hu*, Zhen Geng*, Jiacan Su*. Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy. Theranostics. 2022; 12(15): 6576-6594.（第一作者，医学1区 Top，IF 13.3，封面文章）
28.Han Liu#, Zhen Geng#, Jiacan Su*. Engineered mammalian and bacterial extracellular vesicles as promising nanocarriers for targeted therapy. Extracellular Vesicles and Circulating Nucleic Acids. 2022, 3, 63-86.（第一作者，封面文章，IF 4.8）
29.Xu Xue#, Han Liu#, Sicheng Wang#, Yan Hu, Biaotong Huang, Mengmeng Li, Jie Gao*, Xiuhui Wang*, Jiacan Su*. Neutrophil-erythrocyte hybrid membrane-coated hollow copper sulfide nanoparticles for targeted and photothermal/anti-inflammatory therapy of osteoarthritis. Composites Part B-Engineering. 2022, 237, 109855.（共同一作，材料科学1区 Top，IF：14.2，ESI高被引）
30.Xu Xue#, Hao Zhang#, Han Liu#, Sicheng Wang#, Jiadong Li, Qirong Zhou, Xiao Chen, Xiaoxiang Ren, Yingying Jing, Yonghui Deng*, Zhen Geng*, Xiuhui Wang*, Jiacan Su*. Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration. Advanced Functional Materials. 2022, 2202470, 1-14.（共同一作，材料科学1区 Top，IF 19.0，ESI高被引）
31.Yan Hu#, Jin Cui#, Han Liu#, Sicheng Wang, Qirong Zhou, Hao Zhang, Jiawei Guo, Liehu Cao, Xiao Chen*, Ke Xu*, Jiacan Su*. Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis. RMD Open. 2022, 8, e002314.（共同一作，医学2区，IF 4.7）
32.Xiaoxiang Ren#, Han Liu#, Xianmin Wu#, Weizong Weng*, Xiuhui Wang*, Jiacan Su*. Reactive Oxygen Species (ROS)-Responsive Biomaterials for the Treatment of Bone-Related Diseases. Frontiers in Bioengineering and Biotechnology. 2022, 9 (1381). （共同一作，工程技术3区，IF：4.8，ESI高被引）
33.Han Liu, Yu Wang, Yehua Hou, Zhimin Li*. Fitness of chassis cells and metabolic pathways for L-cysteine overproduction in Escherichia coli. Journal of Agricultural and Food Chemistry. 2020. 68, 50, 14928-14937.（第一作者，农林科学1区 Top, IF 6.2）
34.Han Liu, Yehua Hou, Yu Wang, Zhimin Li*. Enhancement of sulfur conversion rate in the production of L-cysteine by engineering Escherichia coli. Journal of Agricultural and Food Chemistry. 2020. 68, 250-257.（第一作者，农林科学1区 区 Top, IF 6.2）
35.Han Liu, Guochen Fang, Hui Wu*, Zhimin Li*, Qin Ye. L-cysteine production in Escherichia coli based on rational metabolic engineering and modular strategy. Biotechnology Journal. 2018, e1700695. （第一作者，生物学3区，IF 3.1）
