王栋梁,男,1997年毕业于上海第二医科大学临床医学系英七专业,2003年毕业于上海第二医科大学外科学,获博士学位。从事临床工作25年余,主要临床专业方向为创伤骨科、运动医学;曾赴美国、瑞士等国家专项深造。临床研究方面,以骨质疏松性骨折的防治、肘关节异位骨化机理研究、肩袖损伤的机理研究等为主。基础研究方面,关注关节软骨退行性变化、肩袖损伤机理研究等方向。近期于上海大学转化医学院以及华东理工大学开展关于骨质疏松机理研究等合作。主持或参与国家级等各级课题十余项,共发表论文50余篇,其中SCI论文20余篇,如‘spine Journal(IF=4.166),Compos Part B (IF=9.078),Materials & Design (IF=7.991),J Mater Chem B (IF=6.331),Colloid Surface B (IF=5.268)等,总影响因子>50,单篇最高影响因子9.078分。
主要研究领域:骨质疏松的基础和应用研究,肩袖损伤的基础和应用研究等。
代表性学术成果:
学术论文
1、Dongliang Wang, Guiquan Cai, Hui Wang, Jiye He TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Dev. 2020 Jun 1;29(11):737745. doi: 10.1089/scd.2019.0276.
2、Syed Asadullah, Shiqi Mei, Dongliang Wang, Jie Wei et al. A Sulfonated porous surface of tantalum pentoxide/polyimide composite with micro-submicro structures displaying antibacterial performances and stimulating cell responses. Materials and Design 190 (2020) 108510
3、Weizong Weng, Xiaoqun Li, Dongliang Wang, et al. One-Step Preparation of an AgNP-nHA@RGO Three-Dimensional Porous Scaffold and Its Application in Infected Bone Defect Treatment. International Journal of Nanomedicine. 2020:15 5027–5042
4、Lishu Rena, Songchao Tanga, Dongliang Wang, Jie Wei. Influences of sodium tantalite submicro-particles in polyetheretherketone T based composites on behaviors of rBMSCs/HGE-1 cells for dental application. Colloids and Surfaces B: Biointerfaces 188 (2020) 110723
5、J. Ge, F. Wang, Z. Xu, X. Shen, C. Gao, D. Wang, G. Hu, J. Gu, T. Tang and J. Wei. Influences of niobium pentoxide on roughness, hydrophilicity, surface energy and protein absorption, and cells responses to PEEK based composites for orthopedic applications. J Mater Chem. B, 2020, DOI: 10.1039/C9TB02456E.
6、Xinke Lv, Xuehong Wang, Songchao Tang, Dongliang Wang, Lili Yang, Axiang He, Tingting Tang, Jie Wei. Incorporation of molybdenum disulfide into polyetheretherketone creating T biocomposites with improved mechanical, tribological performances and cytocompatibility for artificial joints applications. Colloids and Surfaces B: Biointerfaces 189 (2020) 110819
7、Guiquan Cai, Hui Wang, Yun Kyung Jung, Zhiyan Xu, Jiahong Zhang, Jiye He, Dongliang Wang, Jung-Woog Shin, Rames Kaewmanee, Saha Nabanita, Jie Wei. Hierarchically porous surface of PEEK/nMCS composite created by femtosecond laser and incorporation of resveratrol exhibiting antibacterial performances and osteogenic activity in vitro. Composites Part B 186 (2020) 107802
8、Syed Asadullah, Han Wu, Shiqi Mei, Deqiang Wang, Yongkang Pan, Dongliang Wang, Jun Zhao, Jie Wei. Preparation, characterization, in vitro bioactivity and rBMSCs responses to tantalum pentoxide/polyimide biocomposites for dental and
orthopedic implants. Composites Part B 177 (2019) 107433
9、Zhengxiang Huang, Guojun Fan, Dongliang Wang. Downregulation of calbindin 1, a calcium-binding protein, reduces the proliferation of osteosarcoma cells. ONCOLOGY LETTERS 13: 3727-3733, 2017
10、Jiye He, Jiahong Zhang and Dongliang Wang. Down-regulation of microRNA-216b inhibits IL-1β-induced chondrocyte injury by up-regulation of Smad3. Bioscience Reports (2017) 37 BSR20160588 DOI: 10.1042/BSR20160588
参编专著
1、老年病学-骨科分册(上册) “老年骨与关节损伤、疾病的流行病学”与“肘关损伤(肘关节腱性病变、肘关节挛缩、异位骨化)”相关章节(待出版)
2、侯树勋 主编。《骨科学目录》(1895,500)人民卫生出版社 2012
学术奖项
2020年度上海大学转化医学科技成果一等奖
科研项目:
1. 军科委重点项目“艇员睡眠/唤醒辅助技术研究”编号:19-163-12-ZD-018-05-01;2020.11.01~2021.10.30,项目经费100万元人民币,分支课题负责人。
2.上海市科委:“肩关节肩袖损伤大鼠动物模型等构建及病理机制研究”,项目编号21140904900,2021-6-30~2024-6-30,项目经费22万元人民币,项目负责人。
3. 上海申康管理公司,2020年度临床科技创新项目:“数字技术辅助ACL双束八股解剖重建治疗的精准化、标准化、个性化应用与推广”项目编号:SHDC12020118,2020-12-01~2023-11-30,项目总经费100万元人民币,多中心研究子课题负责人。
社会学术兼职
上海大学转化医学研究院特聘教授;上海医师志愿者联盟首席专家;中国老年学和老年医学会老年病学分会常委兼(上海)骨科专家委员会主任委员;上海医学会骨科专委会创伤学组委员;上海中西医结合学会骨质疏松专业委员会副主任委员;上海医学会创伤分会运动医学学组委员;中国骨质疏松防治联盟创始理事;上海肘疾病与技术协作组委员;《中华创伤杂志》编委;《Chinese Medicine Journal》审稿。