nanboshan1987@163.com
耿振，副研究员，博士研究生导师，UCLA访问学者。硕博阶段：师从天津大学杨贤金教授，从事医用金属表面改性和生物活性磷灰石的制备与评价等研究工作；博士后阶段：师从华东理工大学刘昌胜院士，从事骨性关节炎及骨修复等研究工作。博士后出站，入职上海大学转化医学研究，聚焦骨/软骨疾病，从事关于骨/软骨修复生物医用材料（涉及水凝胶、软骨类器官等）的研发和评价等工作，以一作/通讯在Natl. Sci. Rev., Nano Lett., Adv. Funct. Mater., Bioact. Mater., Chem. Eng. J., Theranostics, Mater. Horiz., Compos. Part B-Eng., J. Mater. Sci. Technol.等期刊发表SCI论文40余篇，主持/参与国家重点研发计划重点专项课题、国家自然科学基金、博士后面上项目和特别资助项目、省部级基金等10余项。
主要研究领域：
1. 关节软骨类器官的构建与应用
2. 骨/软骨修复生物材料
3. 关节炎治疗
代表性学术成果：
1. Zhen Geng, Xiaogang Wang, Yuanman Yu, Luli Ji, Jing Wang*, Changsheng Liu*. Attenuating osteoarthritis by a high effcient anti-bone resorption injectable pH-responsive bisphosphonate-conjugated nano-apatite system. Chemical Engineering Journal, 2020, 420, 127674.
2. Zhen Geng, Luli Ji, Zhaoyang Li*, Jing Wang*, Hongyan He, Zhenduo Cui, Xianjin Yang, Changsheng Liu. Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis. Bioactive Materials, 2021, 6, 905-915.
3. Zhen Geng, Zhaoyang Li, Zhenduo Cui, Jing Wang*, Xianjin Yang, Changsheng Liu*. Novel Bionic Topography with MiR-21 Coating for Improving Bone Implant Integration through Regulating Cell Adhesion and Angiogenesis. Nano Letters, 2020, 20, 7716-7721.
4. Xu Xue1, Hao Zhang1, Han Liu1, Sicheng Wang1, Jiadong Li, Qirong Zhou, Xiao Chen, Xiaoxiang Ren, Yingying Jing, Yonghui Deng*, Zhen Geng*, Xiuhui Wang*, Jiacan Su*. Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration. Advanced Functional Materials, 2022, 2202470.
5. Ziyang Zhou1, Jin Cui1, Shunli Wu1, Zhen Geng*, Jiacan Su*. Silk Fibroin-Based Biomaterials for Cartilage/Osteochondral Repair. Theranostics, 2022, 12, 5103-5124.
6. Yili Wang1, Hao Zhang1, Yan Hu1, Yingying Jing*, Zhen Geng*, Jiacan Su*. Bone repair biomaterials: a perspective from immunomodulatory. Advanced Functional Materials, 2022, 32, 2208639.
7. Ziyang Zhou1, Peiran Song1, Yan Wu1, Miaomiao Wang1, Congyi Shen, Zhixin Ma, Xiaoxiang Ren, Xiuhui Wang, Xiao chen, Yan Hu, Zuhao Li, Qin Zhang*, Mengmeng Li*, Zhen Geng*, Jiacan Su*. Dual-network DNA-Silk fibroin hydrogels with controllable surface rigidity for regulating chondrogenic differentiation. Materials Horizons, 2024, 11, 1465-1483.
8. Fanying Meng1, Guangchao Wang1, Fengjin Zhou1, Guangfeng Li1, Mingkai Wang, Ziyang Zhou, Yafei Han, Xiao Chen, Yan Hu, Yuanwei Zhang, Xiuhui Wang*, Yuan Chen*, Zhen Geng*, Jiacan Su*. Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell. Composites Part B: Engineering, 2024, 276, 111358.
9. Kai Dai1, Zhen Geng1, Wenchao Zhang1, Xue Wei, Jing Wang*, Guangjun Nie*, Changsheng Liu*. Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts. National Science Review, 2024, 11, nwae076.
10. Congyi Shen1, Jian Wang1, Guangfeng Li1, Shuyue Hao1, Yan Wu, Peiran Song, Yafei Han, Mengmeng Li, Guangchao Wang, Ke Xu, Hao Zhang, Xiaoxiang Ren, Yingying Jing*, Ru Yang*, Zhen Geng*, Jiacan Su*. Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor. Bioactive Materials, 2024, 35, 429-444.
学术奖项：
无
科研项目：
1. 国家科技部重点研发计划“高端功能与智能材料”重点专项，微创治疗用活性组织修复材料的研制及临床前研究，课题2“PCPC用于微创治疗椎体压缩性骨折的临床前研究”，2022.11-2025.10，150万，在研，课题负责人。
2. 国家自然科学基金青年科学基金，锶掺杂磷灰石介导成骨-破骨调控软骨下骨稳态平衡的机制研究，2022.1-2024.12，30万元，在研，主持。
3. 2023年上海市创新医疗器械应用示范项目，自固化磷酸钙人工骨应用示范项目，子课题“CPC的材料学改性研究”，8万元，在研，主持。
4. 中国博士后科学基金特别资助，锶掺杂磷灰石调控骨稳态平衡防治骨性关节炎的机制研究，2021.07-2021.08，18万元，已结题，主持。
5. 中国博士后科学基金面上项目一等资助，2018M640350，pH 响应性纳米磷灰石载药体系用于治疗骨性关节炎的研究，2019.01-2021.08，8 万元，已结题，主持。
社会学术兼职：
无
