研究方向：

1、骨类器官基质材料的开发

2、骨修复生物活性材料设计

3、仿生骨修复材料构建策略

研究中心主任：

白龙 副研究员、硕士研究生导师

研究中心成员：

刘晗 副研究员、博士研究生导师  王秀惠 副研究员、硕士研究生导师                 吴琰 博士后                                宋沛然 博士后                

研究中心代表作：

1.Xiaoxiang Ren#, Xiao Chen#, Zhen Geng#, Jiacan Su*, Bone-targeted biomaterials: strategies and applications. Chemical Engineering Journal, 2022, 46, 137133 (IF 16.744)

2.Shuming Sun, Han Liu, Yan Hu, Yanpeng Wang, Mingri Zhao, Yijun Yuan, Yafei Han, Yinging Jing, Jin Cui*, Xiaoxiang Ren*, Xiao Chen*, Jiacan Su*. Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle, Bioactive Materials, 2022, 20, 166-178（IF 16.874）

3.Xiaoxiang Ren#, Ruifang Gao#, Henny C. van der Mei*, Yijin Ren, Brandon W. Peterson, Henk J. Busscher, Eradicating infecting bacteria while maintaining tissue integration on photothermal nanoparticle-coated titanium surfaces, ACS Applied Materials and Interfaces, 2020, 31, 34610-34619 （IF 10.383）

4.Xiaoxiang Ren, Henny C. van der Mei*, Yijin Ren, Henk J. Busscher, Keratinocytes protect soft-tissue integration of dental implant materials against bacterial challenges in a 3D-tissue infection model, Acta Biomaterialia, 2019, 96, 237-246（IF 10.633）

5.Qin Zhang, Qiaomei Tang, Yuwei Yang, Junzhi Yi, Wei Wei, Yi Hong, Xianzhu Zhang, Feifei Zhou, Xudong Yao, Hongwei Ouyang. Wound dressing gel with resisted bacterial penetration and enhanced re-epithelization for corneal epithelial-stromal regeneration. Applied Materials Today, 2021, 24: 101119. (IF=8.663)

6.Haitao Sun#,Qin Zhang#, Jingchao Li, Shaojun Peng*, Xiaolin Wang*, Rong Cai*. Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy. Nano Today, 2020, 37 (2021) 101073. (IF=20.722)

7.Xu Xue#, Hao Zhang#, Han Liu#, Sicheng Wang#, Jiadong Li, Qirong Zhou, Xiao Chen, Xiaoxiang Ren, Yingying Jing, Yonghui Deng*, Zhen Geng*, Xiuhui Wang*, Jiacan Su*, Rational design of multifunctional CuS nanoparticle-PEG composite soft hydrogel coated-3D hard polycaprolactone scaffolds for efficient bone regeneration, Advanced Functional Materials, 2022, 32, 2202470. (IF: 19.924)

8.Xu Xue#, Han Liu#, Sicheng Wang#, Yan Hu, Biaotong Huang, Mengmeng Li, Jie Gao*, Xiuhui Wang*, Jiacan Su*, Neutrophil-erythrocyte hybrid membrane-coated hollow copper sulfide nanoparticles for targeted and photothermal/ anti-inflammatory therapy of osteoarthritis, Composites Part B, 2022, 237, 109855. (IF: 11.322)

9.Lunguo Xia#, Youtao Xie#, Bing Fang, Xiuhui Wang*, Kaili Lin*, In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants, Chemical Engineering Journal, 2018, 347, 711. (IF: 16.744)

10.Shunli Wu#, Xianmin Wu#, Xiuhui Wang*, Jiacan Su*, The hydrogels for bone organoid construction: from a materiobiological perspective, Journal of Materials Science & Technology, 2023, 136, 21-31. (IF: 10.319)

11.Haitao Sun#, Tianzhu Yu#, Xin Li#, Yangyang Lei, Jianke Li, Xiuhui Wang*, Peike Peng*, Dalong Ni, Xiaolin Wang*, Yu Luo*, Second near-infrared photothermal- amplified immunotherapy using photoactivatable composite nanostimulators, Journal of Nanobiotechnology, 2021, 19, 433. (IF: 10.435)

12. Jiansheng Liu#, Jiajia Li#, Shu Zhang#, Mengbin Ding, Ningyue Yu, Jingchao Li*, Xiuhui Wang*, Zhaohui Li*, Antibody-conjugated gold nanoparticles as nanotransducers for second near-infrared photo-stimulation of neurons in rats, Nano Convergence, 2022, 9, 13. (IF: 10.038)

13. Xingge Yu#, Xiuhui Wang#, Dejian Li#, Ruilong Sheng, Yifang Qian, Rui Zhu*, Xudong Wang*, Kaili Lin*, Mechanically reinforced injectable bioactive nanocomposite hydrogels for in-situ bone regeneration, Chemical Engineering Journal, 2022, 433, 132799. (IF: 16.744)

14.1. Ziqing Wu,# Hao Zhang,# Jing Yan,# Yan Wei,* Jiacan Su.* Engineered biomembrane-derived nanoparticles for nanoscale theranostics. Theranostics 2023, 13, 20-39. (IF = 11.600)

15.Yali Tao,# Yutong Chen,# Sicheng Wang,# Weikai Chen, Dongyang Zhou, Dagui Chen, Chenxi Zhang, Ziqing Wu, Jing Yan, Hao Zhang,* Yan Wei,* Jiacan Su.* Optimizing the Modification Density of Acid Oligopeptides to Enhance the Bone-Targeting Activity of Liposomes. Composites Part B: Engineering 2022, 110288. (IF = 11.322)

16. Nianxiu Duan,# Junjun Li,# Sha Song, Feng Wang, Yiwei Yang, Di Nie, Caifen Wang, Yingjie Sheng, Yali Tao, Jie Gao, Can Xu,* Yan Wei,* Gan, Y. Enzyme‐Activated Prodrug‐Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells. Advanced Functional Materials 2021, 2100605. (IF = 18.808)

17. Yan Wei,# Sha Song,# Nianxiu Duan, Feng Wang, Yuxi Wang, Yiwei Yang, Chengyuan Peng, Junjun Li, Di Nie, Xinxin Zhang, Shiyan Guo, Chunliu Zhu, Miaorong Yu, Yong Gan.* MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy. Advanced Science 2020, 1902746. (IF = 16.806)

18. Jinxu Cao, Peng Yang, Pengzhen Wang, Shuting Xu, Yunlong Cheng, Kang Qian, Minjun Xu, Dongyu Sheng, Yixian Li, Yan Wei,* Qizhi Zhang.* 'Adhesion and Release' Nanoparticle-Mediated Efficient Inhibition of Platelet Activation Disrupts Endothelial Barriers for Enhanced Drug Delivery in Tumors. Biomaterials 2020, 269, 120620. (IF = 12.479)