研究方向：

1. 应用于衰老相关疾病的纳米靶向生物材料的开发及转化研究

2. 3D打印生物墨水的合成及其构建多功能骨类器官研究

研究中心主任：

魏彦 副研究员、博士研究生导师

研究中心成员：

任肖湘 助理研究员        周东阳 博士后    

1. Duan, N.^#; Li, J.^#; Song, S.; Wang, F.; Yang, Y.; Nie, D.; Wang, C.; Sheng, Y.; Tao, Y.; Gao, J.; Xu, C.*; Wei, Y.*; Gan, Y. Enzyme‐Activated Prodrug‐Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells. Adv. Funct. Mater. 2021, 2100605. DOI: 10.1002/adfm.202100605. (IF = 18.808)

2. Wei, Y.^#; Song, S.^#; Duan, N.; Wang, F.; Wang, Y.; Yang, Y.; Peng, C.; Li, J.; Nie, D.; Zhang, X.; Guo, S.; Zhu, C.; Yu, M.; Gan, Y*. Mt1‐Mmp‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy. Adv. Sci. 2020, 1902746. DOI: 10.1002/advs.201902746. (IF = 16.806)

3. Cao, J.^#; Wu, J.^#; Yang, P.; Qian, K.; Cheng, Y.; Xu, M.; Sheng, D.; Meng, R.; Wang, T.; Li, Y.; Wei, Y.*; Zhang, Q*. Dual Enzyme Cascade-Activated Popcorn-Like Nanoparticles Efficiently Remodeled Stellate Cells to Alleviate Pancreatic Desmoplasia. ACS Nano. 2023, 17(20), 19793-19809. DOI: 10.1021/acsnano.3c03838. (IF = 17.1)

4. Cao, J.; Yang, P.; Wang, P.; Xu, S.; Cheng, Y.; Qian, K.; Xu, M.; Sheng, D.; Li, Y.; Wei, Y.*; Zhang, Q*. 'Adhesion and Release' Nanoparticle-Mediated Efficient Inhibition of Platelet Activation Disrupts Endothelial Barriers for Enhanced Drug Delivery in Tumors. Biomaterials. 2020, 269, 120620. DOI: 10.1016/j.biomaterials.2020.120620. (IF = 12.479)

5. Yan, J.^#; Wang, M.^#; Lv, S.^#; Chen, D.; Wu, Z.; Zhou, D.; Zhang, S.; Lv, J.; Xu, K.*; Xu, C*.; Wei, Y*. SiATG5-Loaded Cancer Cell Membrane-Fused Liposomes Induced Increased Uptake of Albumin-Bound Chemotherapeutics by Pancreatic Cancer Cells. J. Controlled Release. 2024, 367, 620-636. DOI: 10.1016/j.jconrel.2024.01.055. (IF = 10.8)

6. Zhou, D.^#; Wei, Y.^#,*; Sheng, S.^#; Wang, M.^#; Lv, J.; Zhao, B.; Chen, X.; Xu, K.; Bai, L.; Wu, Y.; Song, P.; Cao, L.; Zhou, F.*; Zhang, H.*; Shi, Z.*; Su, J*. MMP13-Targeted SiRNA-Loaded Micelles for Diagnosis and Treatment of Posttraumatic Osteoarthritis. Bioact. Mater. 2024, 37, 378-392. DOI: 10.1016/j.bioactmat.2024.04.010. (IF = 18.9)

7. Jian Wang, Yan Wu, Guangfeng Li, Fengjin Zhou, Xiang Wu, Miaomiao Wang, Xinru Liu, Hua Tang, Long Bai, Zhen Geng, Peiran Song*, Zhongmin Shi*, Xiaoxiang Ren*, Jiacan Su*，Engineering Large‐Scale Self‐Mineralizing Bone Organoids with Bone Matrix‐Inspired Hydroxyapatite Hybrid Bioinks，Adv. Mater., 2024，2309875（IF = 29.4）

8. Xiaoxiang Ren, Jian Wang, Yan Wu, Yuan Zhang, Jieyuan Zhang, Long Bai, Jinlong Liu, Guangfeng Li*, Peiran Song*, Zhongmin Shi*, Jiacan Su*，One-pot synthesis of hydroxyapatite hybrid bioinks for digital light processing 3D printing in bone regeneration，Journal of Materials Science & Technology 2024，188, 84-97（IF = 10.9）

9. Yuan Zhang, Guangfeng Li, Jian Wang, Fengjin Zhou,* Xiaoxiang Ren,* Jiacan Su*，Small joint organoids 3D bioprinting: construction strategy and application，Small 20 (8), 2302506（IF = 13.3，封面文章）

10. Xiaoxiang Ren, Xiao Chen, Zhen Geng, Jiacan Su*, Bone-targeted biomaterials: strategies and applications. Chemical Engineering Journal, 2022, 46, 137133 (IF = 16.744)

11. Shuming Sun, Han Liu, Yan Hu, Yanpeng Wang, Mingri Zhao, Yijun Yuan, Yafei Han, Yinging Jing, Jin Cui*, Xiaoxiang Ren*, Xiao Chen*, Jiacan Su*. Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle, Bioact. Mater., 2022, 20, 166-178（IF = 16.874，封面文章）