研究方向：

1. STING与运动系统损伤及退行性病变的相关性研究

2. STING调控天然免疫系统的分子机制研究

3. 靶向STING的中药及天然药物研究开发

4. 靶向STING的多肽药物研究开发

研究中心主任：

苏笠 副教授、博士研究生导师           赵亮 主任药师、行业导师      

研究中心成员：

刘莹 副研究员

研究中心代表作：

1. Huihui Bian^#, Junjie Wang^#, Xiaodong Shan, Xiuqing Li, Yongjin Wang, Rui Sun, Chongxian Wang, Juan Lv, Chunlei Xing, Chunlei Hui, Dinglei Zhang, Chenxi Zhang, Yuyan Zhang, Yangbo Zhao, Chenguang Tian*, Yuanqing Gao*, Li Su*. A portable on-demand therapeutic nitric oxide generation apparatus: New strategy for diabetic foot ulcers. Chemical Engineering Journal, https://doi.org/10.1016/j.cej.2023.148088

2. Yuhong Chen^#, Huihui Bian^#, Juan Lv^#, Wanxue Song, Chunlei Xing, Chunlei Hui, Dinglei Zhang, Chenxi Zhang, Liang Zhao^*, Yingke Li^*, Li Su*. Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis. Frontiers in Immunology. 2023 July 31, https://doi.org/10.3389/fimmu.2023.1190707.

3. Chunlei Xing^#, Juan Lv^#, Zhihui Zhu^#, Wei Cong, Huihui Bian, Chenxi Zhang, Ruxin Gu, Dagui Chen, Xiying Tan^*, Li Su^*, Yu Zhang^*. Regulation of microglia related neuroinflammation contributes to the protective effect of Gelsevirine on ischemic stroke. Frontiers in Immunology. 2023 March 30; Volume 14, https://doi.org/10.3389/fimmu.2023.1164278.

4. Kang Fu^#, Chunlei Hui^#, Xinyuan Wang, Tingting Ji, Xiuqing Li, Rui Sun, Chunlei Xing, Xi Fan, Yuanqing Gao^*, Li Su^*. Torpor-like Hypothermia Induced by A1 Adenosine Receptor Agonist: A Novel Approach to Protect against Neuroinflammation. International Journal of Molecular Sciences, 2023 Jul 3; 24(13):11036. doi: 10.3390/ijms241311036.

5. Kong Depei, Ye Chen, Zhang Chenxi, Sun Xiaochen, Wang Fubo, Chen Rui, Xiao Guangan, He Shipeng, Xu Jiarong, Rao Xiwu, Ai Jianzhong, Gao Xu, Li Hong^*, Su Li^*. Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer. J Exp Clin Cancer Res. 2023 Feb 9;42(1):45, https://doi: 10.1186/s13046-023-02610-7.

6. Xiaochen Sun^#, Yi Zhang^#, Jin Cui^#, Chenxi Zhang, Chunlei Xing, Huihui Bian, Juan Lv, Dagui Chen, Lan Xiao, Jiacan Su^*, Yuanyuan Liu^*, Li Su^*. Advanced multilayer composite dressing with co-delivery of gelsevirine and silk fibroin for burn wound healing. J Composites Part B: Engineering, Volume 253, 2023, 110549, https://doi.org/10.1016/j.compositesb.2023.110549.

7. Meixia Feng^#, Depei Kong^#, Huan Guo^#, Chunlei Xing, Juan Lv, Huihui Bian, Nanning Lv, Chenxi Zhang, Dagui Chen, Mingming Liu^*, Yongsheng Yu^* and Li Su^*.  Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation. Biochemical Pharmacology, 2022 Apr;198:114975, https://doi: 10.1016/j.bcp.2022.114975.

8. Chenxi Zhang^#, Ye Tu^#, Xiaochen Sun^#, Dagui Chen, Wannian Zhang, Chunlin Zhuang^*, Zhibin Wang^*, Li Su^*. Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects. Front Immunol. 2022 Feb 28;13:856327, https://doi: 10.3389/fimmu.2022.856327.

9. Yongsheng Yu^#, Huan Guo^#, Wenli Jiang, Chenxi Zhang, Chunlei Xing, Dagui Chen, Can Xu^*, Li Su^*. Cyclic GMP-AMP promotes the acute phase response and protects against Escherichia coli infection in mice. Biochemical Pharmacology, 2021 Jun;188:114541, https://doi: 10.1016/j.bcp.2021.114541.

10. Li Su^#, Ye Tu ^#, Depei Kong^#, Dagui Chen, Chenxi Zhang, Wannian Zhang, Chunlin Zhuang^*, Zhibin Wang^*. Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents[J]. Biomedicine & Pharmacotherapy, 2020, 131:110643, https://doi: 10.1016/j.biopha.2020.110643.