研究方向：
1. 软骨类器官构建与应用
2. 软骨类器官水凝胶研发
3. 骨与关节软骨再生修复
研究中心主任：
耿振 副研究员、博士研究生导师
成员：
李蒙蒙 助理研究员、硕士研究生导师
代表性学术成果：
1. Zhen Geng, Xiaogang Wang, Yuanman Yu, Luli Ji, Jing Wang*, Changsheng Liu*. Attenuating osteoarthritis by a high effcient anti-bone resorption injectable pH-responsive bisphosphonate-conjugated nano-apatite system. Chemical Engineering Journal, 2020, 420, 127674.
2. Zhen Geng, Luli Ji, Zhaoyang Li*, Jing Wang*, Hongyan He, Zhenduo Cui, Xianjin Yang, Changsheng Liu. Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis. Bioactive Materials, 2021, 6, 905-915.
3. Zhen Geng, Zhaoyang Li, Zhenduo Cui, Jing Wang*, Xianjin Yang, Changsheng Liu*. Novel Bionic Topography with MiR-21 Coating for Improving Bone Implant Integration through Regulating Cell Adhesion and Angiogenesis. Nano Letters, 2020, 20, 7716-7721.
4. Xu Xue1, Hao Zhang1, Han Liu1, Sicheng Wang1, Jiadong Li, Qirong Zhou, Xiao Chen, Xiaoxiang Ren, Yingying Jing, Yonghui Deng*, Zhen Geng*, Xiuhui Wang*, Jiacan Su*. Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration. Advanced Functional Materials, 2022, 2202470.
5. Ziyang Zhou1, Jin Cui1, Shunli Wu1, Zhen Geng*, Jiacan Su*. Silk Fibroin-Based Biomaterials for Cartilage/Osteochondral Repair. Theranostics, 2022, 12, 5103-5124.
6. Yili Wang1, Hao Zhang1, Yan Hu1, Yingying Jing*, Zhen Geng*, Jiacan Su*. Bone repair biomaterials: a perspective from immunomodulatory. Advanced Functional Materials, 2022, 32, 2208639.
7. Ziyang Zhou1, Peiran Song1, Yan Wu1, Miaomiao Wang1, Congyi Shen, Zhixin Ma, Xiaoxiang Ren, Xiuhui Wang, Xiao chen, Yan Hu, Zuhao Li, Qin Zhang*, Mengmeng Li*, Zhen Geng*, Jiacan Su*. Dual-network DNA-Silk fibroin hydrogels with controllable surface rigidity for regulating chondrogenic differentiation. Materials Horizons, 2024, 11, 1465-1483.
8. Fanying Meng1, Guangchao Wang1, Fengjin Zhou1, Guangfeng Li1, Mingkai Wang, Ziyang Zhou, Yafei Han, Xiao Chen, Yan Hu, Yuanwei Zhang, Xiuhui Wang*, Yuan Chen*, Zhen Geng*, Jiacan Su*. Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell. Composites Part B: Engineering, 2024, 276, 111358.
9. Kai Dai1, Zhen Geng1, Wenchao Zhang1, Xue Wei, Jing Wang*, Guangjun Nie*, Changsheng Liu*. Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts. National Science Review, 2024, 11, nwae076.
10. Congyi Shen1, Jian Wang1, Guangfeng Li1, Shuyue Hao1, Yan Wu, Peiran Song, Yafei Han, Mengmeng Li, Guangchao Wang, Ke Xu, Hao Zhang, Xiaoxiang Ren, Yingying Jing*, Ru Yang*, Zhen Geng*, Jiacan Su*. Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor. Bioactive Materials, 2024, 35, 429-444.
11. Mengmeng Li1, Hongshi Ma1, Fei Han, Dong Zhai, Bingjun Zhang, Yuhua Sun, Tian Li, Lei Chen, Chengtie Wu*. Microbially catalyzed biomaterials for bone regeneration. Advanced Materials, 2021, 33: 2104829.
