研究方向：
1、聚焦肿瘤骨转移类器官构建及应用探索；
2、阐明骨衰老分子机制与骨转移的关联；
3、构建靶向骨衰老的骨转移类器官芯片；
代表性学术成果：
1. Gu Y, Zhou Q, Sheng S, Yang H, Huang D, Zhang Q, Zhang H, Cao Z, Zhang Y, Li Z, Jiang Y, Chen X, Jing Y, Wang C, Tan H, Xu K, Su J. Bone remodeling stimulated by Wnt-mediated mitophagy regulated extracellular vesicles in subchondral bone contributes to osteoarthritis development. Theranostics. 2025 Sep 21; 15(18): 10007-10027.
2. Li R, Wu Y, Zheng Z, Zhou F, Xu K, Su J. Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects. MedComm (2020). 2026 Jan 5;7(1):e70575.
3. Liu H, Li R, Yang H, Situ B, Wang G, Xu K, Su J. Extracellular Vesicles in Gut-Bone Axis: Novel Insights and Therapeutic Opportunities for Osteoporosis. Small Sci. 2024 Dec 23;5(4):2400474.
4. Wang J, Zhou D, Li R, Sheng S, Li G, Sun Y, Wang P, Mo Y, Liu H, Chen X, Geng Z, Zhang Q, Jing Y, Bai L, Xu K, Su J. Protocol for engineering bone organoids from mesenchymal stem cells. Bioact Mater. 2024 Dec 1;45:388-400.
5. Chen Y, Li J, Liu X, Geng Z, Xu K, Su J. Advances in biomarkers and diagnostic significance of organ aging. Fundam Res. 2023 Apr 9;5(2):683-696.
6. Chen Y, Wang G, Zhou F, Yin Z, Shen F, Weng W, Zhang H, Jiang Y, Liu X, Deng Y, Chen Y, Xu K, Su J. Targeting TRPA1 with liposome-encapsulated drugs anchored to microspheres for effective osteoarthritis treatment, Chinese Chemical Letters 36 (2025) 110053
7. Jiang Y, Li J, Xue X, Yin Z, Xu K, Su J. Engineered extracellular vesicles for bone therapy, Nano Today, 2022, 44: 101487
8. Yuan Z, Fan G, Wu H, Liu C, Zhan Y, Qiu Y, Shou C, Gao F, Zhang J, Yin P, Xu K. Photodynamic Therapy Synergize with PD-L1 Checkpoint Blockade for Immunotherapy of Colorectal Cancer by Multifunctional Nanoparticle. Molecular Therapy. 2021 Oct 6;29(10):2931-2948.
9. Xu K#*, Zhan Y#, Yuan Z#, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X*, Yin P*. Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop. Molecular Therapy. 2019 Oct 2;27(10):1810-1824.
10. Xu K, Park D, Magis AT, Zhang J, Zhou W, Sica GL, Ramalingam SS, Curran WJ, Deng X*. Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. Molecular Cancer. 2019 Apr 10;18(1):85.
